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By Mcintosh M. W.

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Duenas-Gonzales A. Phase III, open-label, randomized study comparing concurrent gemcitabine plus cisplatin and radiation followed by adjuvant gemcitabine and cisplatin vs. concurrent cisplatin and radiation in patients with stage IIB to IVA carcinoma of the cervix. J Clin Oncol. 2011;29(13):1678–1685. DESIGN SERVICES OF 2C Ovarian Cancer I.  One in 70 women will develop ovarian cancer in their lifetime. In 2013, 22,240 new cases are approximated, and 14,030 deaths. Ovarian cancer is most commonly found at Stage III and most women die from bowel obstruction.

64 for intraoperative cyst rupture (8). VI. Chemotherapy for epithelial ovarian cancer:  latinum-sensitive and platinum-resistant disease. Platinum P ­resistance is defined as disease recurrence less than 6 months after DESIGN SERVICES OF OF 2C. Ovarian Cancer 45 completion of first-line platinum-based chemotherapy. If recurrence occurs at less than 6 months, non-platinum-based salvage therapies should be used; if greater than 6 months pass between completion of first-line platinum-based chemotherapy and recurrence, re-attempts with platinum-based regimens should be used.

8 months, again, all favoring paclitaxel.  GOG 132 (23): This trial evaluated 648 suboptimal Stage III and any Stage IV patients. There were 3 arms: a doublet of cisplatin and paclitaxel dosed at 75 mg/kg and 135 mg/kg; single-agent paclitaxel dosed at 200 mg/kg; single-agent cisplatin dosed at 100 mg/kg. The PFS, respectively, was 14 months, 11 months, and 16 months. The, OS respectively, was 26 months, 26 months, and 30 months. The response rate was, respectively, 67%, 67%, and 47%.  GOG 157 (24): This trial evaluated 3 vs.

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