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By Paul H. Sugarbaker MD, FACS, FRCS (auth.), Santiago González-Moreno MD, PhD (eds.)

S. González-Moreno (Ed. ) Advances in Peritoneal floor Oncology With forty five Figures in fifty seven Separate Illustrations, 12 in colour and 19 Tables 123 IV Preface Santiago González-Moreno, MD, PhD division of Surgical Oncology Centro Oncológico MD Anderson foreign España Calle Gómez Hemans 2 28033 Madrid Spain sgonzalez@mdanderson. es Library of Congress keep an eye on quantity: 2006937141 ISSN 0080-0015 ISBN 978-3-540-30759-4 Springer Berlin Heidelberg long island This paintings is topic to copyright. All rights are reserved, even if the entire or a part of the cloth is anxious, speci? ?cally the rights of translation, reprinting, reuse of illustrations, recitations, broadcasting, copy on micro? ?lm or in the other method, and garage in facts banks. Duplication of this ebook or components thereof is authorized merely lower than the provisions of the German Copyright legislation of September nine, 1965, in its present model, and permission to be used should always be got from Springer-Verlag. Violations are answerable for prosecution below the German Copyright legislation. Springer is a part of Springer Science+Business Media http//www. springer. com Springer-Verlag Berlin Heidelberg 2007 published in Germany using basic descriptive names, emblems, and so forth. during this e-book doesn't suggest, even within the absence of a speci? ?c sta- ment, that such names are exempt from the proper protecting legislation and laws and hence unfastened for basic use. Product legal responsibility: The publishers can't warrantly the accuracy of any information regarding dosage and alertness contained during this publication. In each case the person needs to payment such info by way of consulting the proper literature.

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Arch Pathol Lab Med 124:1016–1025 10. Compton CC (2003) Colorectal carcinoma: diagnostic, prognostic, and molecular features. Mod Pathol 16:376–388 11. Shepherd NA, Baxter KJ, Love SB (1995) Influence of local peritoneal involvement on pelvic recurrence and prognosis in rectal cancer. J Clin Pathol 48:849– 855 12. Douard R, Cugnenc P-H, Wind P, Benichou J (2004) Peritoneal involvement and free tumor cells in peritoneal cavity of patients with colon cancer. Am J Clin Pathol 121:154–155 13. Knudsen PJ (1991) The peritoneal elastic lamina.

Peritoneal involvement by colonic adenocarcinoma (Figs. 4) has been shown to be the parameter of supreme prognostic importance in all-comers with the disease [6] and, especially, in Dukes B colonic cancer [7]. In one of our colonic cancer studies, we showed it to have the strongest independent prognostic significance, even more powerful than the extent of local spread or lymph node involvement [6]. In the ACPS studies of colonic cancer, it has been shown to be the second most important prognostic feature after the number of involved lymph nodes [2, 47–49].

In primary resections of colonic carcinoma, up to 55% of specimens will show serosal involvement [6, 51] and IPTC have been found in up to 43% of patients with colorectal carcinoma at the time of resection [16]. In a study of the characteristics of colorectal tumours most likely to exfoliate cells into the peritoneal space, macroscopic breach of the peritoneal surface and invasion of the serosal surface were two of the seven factors predicting such exfoliation [52]. A mucinous adenocarcinoma phenotype is also a significant factor leading to serosal involvement [6].

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